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Symbol
Name
ID
Foxn1
forkhead box N1
MGI:102949
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Decreased helper T cell proportion
T lymphocytopenia
Immunodeficiency
Severe T-cell immunodeficiency
Disease(s) Associated with FOXN1
T-cell immunodeficiency, congenital alopecia, and nail dystrophy

Mouse Phenotypes
immune system phenotype
increased thymocyte apoptosis
abnormal thymus morphology
abnormal thymus development
abnormal thymus epithelium morphology
absent thymus cortex
abnormal thymus corticomedullary boundary morphology
abnormal thymus medulla morphology
absent thymus medulla
thymus hyperplasia
small thymus
thymus atrophy
thymus hypoplasia
athymia
decreased thymocyte number
increased DN1 thymic pro-T cell number
thymus cyst
abnormal thymus involution
abnormal T cell differentiation
decreased double-negative T cell number
decreased double-positive T cell number
increased double-positive T cell number
increased eosinophil cell number
increased neutrophil cell number
increased granulocyte number
abnormal leukocyte cell number
abnormal lymphocyte cell number
increased B cell number
decreased CD4-positive, alpha-beta T cell number
decreased T cell number
absent T cells
decreased single-positive T cell number
increased T cell number
decreased lymphocyte cell number
decreased leukocyte cell number
abnormal CD4-positive, alpha beta T cell morphology
abnormal CD8-positive, alpha beta T cell morphology
abnormal spleen morphology
small spleen
spleen hypoplasia
abnormal splenic cell ratio
decreased immunoglobulin level
abnormal T cell activation
abnormal circulating cytokine level
decreased circulating interleukin-2 level
decreased circulating interleukin-6 level
decreased circulating tumor necrosis factor level
abnormal immune system morphology
abnormal immune system cell morphology
abnormal immune system organ morphology
abnormal Peyer's patch morphology
abnormal Peyer's patch germinal center morphology
abnormal lymph node morphology
abnormal lymph node T cell domain morphology
lymph node hypoplasia
abnormal immune system physiology
abnormal humoral immune response
abnormal spleen physiology
decreased interferon-gamma secretion
blepharitis
increased incidence of corneal inflammation
decreased susceptibility to bacterial infection
increased susceptibility to Herpesvirales infection induced morbidity/mortality
decreased susceptibility to parasitic infection
increased susceptibility to Herpesvirales infection
increased length of allograft survival
Availability Mouse Genotype
Foxn1nu-2J/Foxn1nu-2J
Foxn1nu-StL/Foxn1nu-StL
Foxn1nu-str/Foxn1nu-str
Foxn1nu-Y/Foxn1nu-Y
Foxn1nu/Foxn1nu
Tg(Foxn1)E1Hon/0
Foxn1nu/Foxn1nu
Foxn1sepe/Foxn1sepe
Foxn1tm1.1(KOMP)Vlcg/Foxn1tm1.1(KOMP)Vlcg
Foxn1tm1.1Cbln/Foxn1tm1.1Cbln
Foxn1tm1Dmsu/Foxn1tm1Dmsu
Foxn1tm1Nrm/Foxn1tm1Nrm
Foxn1tm1Tbo/Foxn1tm1Tbo
Foxn1tm2Nrm/Foxn1tm2Nrm *
Foxn1tm3(cre)Nrm/Foxn1tm3(cre)Nrm *
Foxn1nu-StL/Foxn1tm1Tbo
Foxn1nu/Foxn1+
Foxn1tm1.1Cbln/Foxn1+
Foxn1tm1.1Cbln/Foxn1tm1Tbo
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0  (conditional)
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT18-cre/ERT2)1Rgo/0  (conditional)
*
Foxn1tm2Tbo/Foxn1tm2Tbo
Tg(KRT14-cre/ERT2)1Ipc/0  (conditional)
Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Foxn1tm1.1Cbln/Foxn1+
Tg(Zp3-cre)3Mrt/?  (conditional)
*
Foxn1tm1.1Cbln/Foxn1tm1Tbo
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+  (conditional)
*
Gt(ROSA)26Sortm1(CAG-Foxn1/ERT2,-GFP)Cbln/Gt(ROSA)26Sor+
Foxn1tm3(cre)Nrm/Foxn1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory